Role of the liver in Glucose Metabolism
HI!! subha here .. Today lets see about liver's glucose metabolism - so we can learn base about how diabetes kind of disease are evolving .... Glucose metabolism - liver will capable of both storing and producing glucose . because of this liver plays key role in maintaining the normal plasma glucose levels ~ 5mmol/L - glucose pool in the body is around 60 mmol/L, with food we may ingest upto 3000 mmol/day , muscles may remove up to 250 mmol/hour when we exercise - efficient buffering system is required to prevent excessive and dangerous glucose excursions - while the insulin sensitive tissue they are adipose tissue and muscle will express the glucose transporter , may help to get rid of the most of the glucose arriving from gut to the liver and to a small extent to the kidneys are the only organs that can produce glucose when needed - when glucose is absorbed from the gut, some of it may taken up by the liver, entering the hepatocyte from the sinusoid...